Dr. Yi Zhang Impact on Anesthesiology and Pain Management

Josh Pirtle
Sep 17, 2020

Dr. Yi Zhang MD is a board-certified anesthesiologist and is currently an attending physician at Massachusetts General Hospital, which has been named the number one hospital on the East coast. He is bilingual in Chinese and English, which allows him access to a wider pool of research partners from around the globe. Through his expansive research and collaboration with teams, he has created new baselines for common biochemistry markers.


Dr. Zhang received extensive medical training, and finished his Ph.D. with John Hopkins University School of Medicine, often noted as the top research school in the country. He has focused on biochemistry and anesthesiology throughout his career. He has been an attending physician at Massachusetts General Hospital since the beginning of his career, which is where he also completed his residency and fellowship. 

  • Ph.D., Johns Hopkins University School of Medicine
  • MD, Peking Union Medical College
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital

Clinical Trials and Research Publications

Dr. Zhang’s clinical trials and research publications focus on biochemistry and cell reactions within the human body. His findings are often cited as a baseline in other academic and clinical medical studies, helping to advance modern medicine through the understanding of biochemistry reactions. 

Crystallization kinetics of ammonium polyvanadate

Published in the Journey of Crystal Growth’s 526th volume, Crystallization kinetics of ammonium polyvanadate demonstrated that the morphology of the ammonium polyvandate changes from flake to spherical-like when introduced to phosphorus. Classical primary nucleation theory was used in combination with the induction period. To quote the study results, “the nucleation is homogeneous when with a high supersaturation degree of higher than 25. The critical nucleation radius, free energy, and activation energy decrease, and the nucleation rate increases, with the increase of supersaturation degree.” Understanding these reactions and the energy activations will assist future researchers in crystal growth and in other biochemical study fields. 

The miR-27-a-3p/usp25 axis participates in the pathogenesis of recurrent miscarriage by inhibiting trophoblast migration and invasion

The deficient invasion capacity of trophoblasts may be related to the improvement of the recurrent miscarriage (RM). Ubiquitin‐specific protease 25 (USP25) can direct the procedures of attack and movement in various kinds of malignant growth cells. Be that as it may, the impact of USP25 on trophoblasts and its jobs in the improvement of RM are obscure. In this examination, Dr. Zhang and his fellow researchers broke down the USP25 articulation in placental villous tissues from RM patients, and afterward surveyed the jobs of USP25 in epithelial‐to‐mesenchymal progress (EMT), attack and relocation of trophoblasts. Moreover, bioinformatics expectation and luciferase correspondent tests were utilized to investigate the system of microRNA on USP25 articulation, and a guideline of USP25 articulation in trophoblasts was surveyed following transfection with microRNA impersonates or inhibitor. The outcomes demonstrated that the statement of USP25 in the placental villous tissues was downregulated in RM patients. The knockdown of USP25 smothered the EMT procedure, the attack, and movement capacity of trophoblast cells, while overexpression of USP25 showed inverse outcomes. Unthinkingly, miR‐27a‐3p could control USP25 articulation by authoritative to the 3′‐untranslated locale of USP25 in trophoblasts. Quantitative real‐time polymerase chain response results found the outflow of miR‐27a‐3p was adversely identified with USP25 in RM patients. MiR‐27a‐3p mirrors restrained however miR‐27a‐3p inhibitor improved the relocation and attack ability of trophoblasts. Besides, sh‐USP25 checked the advancement of intrusion and relocation intervened by the miR‐27a‐3p inhibitor. When taken together, this information demonstrates that USP25 downregulation by miR‐27a‐3p adds to the EMT procedure, in this way restraining the movement and attack of trophoblast cells, and these discoveries may give potential biomarkers to RM.

Unconventional Atomic Structure of Graphene Sheets on Solid Substrates

The nuclear structure of free‐standing graphene includes level hexagonal rings with a 2.5 Å period, which is ordinarily viewed as the main nuclear period and decides the extraordinary properties of graphene. Here, a surprising profoundly requested orthorhombic structure of graphene is legitimately seen with a cross-section steady of ≈5 Å, immediately framed on different substrates. First‐principles calculations show that this unusual structure can be ascribed to the dipole between the graphene surface and substrates, which creates an interfacial electric field and actuates nuclear modification on the graphene surface. Further, the arrangement of the orthorhombic structure can be constrained by a falsely created interfacial electric field. Critically, the 5 Å precious stone can be controlled and changed in a persistent and reversible way. Strikingly, the orthorhombic cross-section can control the epitaxial self‐assembly of amyloids. The discoveries uncover new bits of knowledge about the nuclear structure of graphene, and open up new roads to control graphene cross-sections. An epic orthorhombic precious stone of graphene with a 5 Å period framed on different substrates is uncovered and applied to control the epitaxial self‐assembly of amyloids. First‐principles calculations show that this nuclear structure can be ascribed to dipoles between the graphene surface and substrates. A privately produced interfacial electric field is utilized for the controllable development of the nuclear structure.

Social Media Presence

His contributions to anesthesiology breakthroughs, and increased understanding of biochemistry reach far and wide on social media platforms. His research has sparked new conversations, and he has received nearly 500 social media mentions. His colleagues often cite his research, and commend him when sharing new findings. 

Thank you, Dr. Yi Zhang MD, for your continued work in anesthesiology, and commitment to improving the medical world’s understanding of biochemical properties in the human body. H1 looks forward to seeing your future findings and breakthroughs that continue to advance our understandings.